Sanfilippo Syndrome D (MPS IIID)

Mucopolysaccharidosis type IIID (MPS IIID) is a genetic disorder that makes the body unable to break down large sugar molecules called glycosaminoglycans (GAGs, formerly called mucopolysaccharides). Specifically, people with this condition are unable to break down a GAG called heparan sulfate. Affected individuals can have severe neurological symptoms, including progressive dementia, aggressive behavior, hyperactivity, seizures, deafness, loss of vision, and an inability to sleep for more than a few hours at a time. Most people with MPS IIID live into their teenage years, and some live longer.

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